Solid lipid nanoparticles sln have emerged as a nextgeneration drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Formulation and evaluation of solid lipid nanoparticulate gel for antiacne therapy. Research open access formulation and evaluation of chitosan. Formulation development and evaluation of paclitaxel loaded. Mohapatra school of pharmaceutical sciences, soa university, bhubaneswar, odisha03, india. Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine. Preparation, characterization and evaluation of solid lipid. Solid lipid nanoparticle sln technology represents a promising new approach to lipophile drug delivery. To design the formulation of lipid based nanoparticles, it was essential to recognise the parameters in the formulation as these variables can affect the properties of desired formulation. Sep 15, 20 formulation of poloxamer 407 with compritol and drug f9 produced highest in.
Patel college of pharmaceutical education and research, ganpat university, kherva 384012, mehsana, gujarat, india. Slns have been reported as an alternative drug delivery device to traditional polymeric nanoparticles. Nagarsenker department of pharmaceutics, bombay college of pharmacy, santacruz e, mumbai400 098, india padhye and nagarsenker. Formulation and evaluation of gemcitabineloaded solid. Particle sizes of all the formulations were in the range of 250 to 1406 nm, and the entrapment efficiency ranges from 55 to 66%. Formulation and evaluation of solid lipid nanoparticle. Formulation and evaluation of solid lipid nanoparticles containing levosulpiride article pdf available in the open nanomedicine journal 041.
Formulation and evaluation of metoclopramide solid lipid. Download pdf 1206k download meta ris compatible with endnote, reference manager, procite, refworks. Original article formulation and evaluation of solid lipid. Carbamezapine cbz is a lipophilic drug which shows it antiepileptic activity by inactivating sodium channels. Pdf formulation and evaluation of chitosan solid lipid. Formulation and evaluation of solid lipid nanoparticles of prednisolone. Formulation development and evaluation of atorvastatin calcium loaded solid lipid nanoparticles upadhyay n a, mohan g a, sharma s a, shukla t p a, mathur a a, manmohan k anims institute of pharmacy, nims university, shobha nagar, jaipur303121, india. Jun, 2012 solid lipid nanoparticles sln mainly comprise lipids that are in solid phase at the room temperature and surfactants for emulsification, the mean diameters of which range from 50 to nm for colloid drug delivery applications. Formulation and evaluation of solid lipid nanoparticles of ramipril article pdf available in journal of young pharmacists 33. Among various novel colloidal carriers present today, solid lipid nanoparticles slns have versatile potential for safe and nontoxic formulation of cytotoxic drugs, and achieves sitespecific drug release. Formulation, characterization and evaluation of paclitaxel loaded solid lipid nanoparticles prepared by temperature modulated solidification technique. Formulation and invitro evaluation of pravastatin solid.
Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine rahul nair, ashok ck kumar, vishnu k priya, chakrapani m yadav and prasanna y raju abstract the present work aims at preparing aqueous suspension of solid lipid nanoparticles containing chitosan ct which. Formulation and evaluation of morinloaded solid lipid nanoparticles. Formulation, characterization and in vitroin vivo evaluation of ketorolacloaded solid lipid nanoparticles for transdermal delivery meenakshi bhatia and smriti gupta drug delivery research laboratory, dept. Pdf formulation and evaluation of solid lipid nanoparticles.
Raloxifene hydrochloride rlhcl is an orally selective estrogen receptor modulator serm with poor bioavailability of nearly 2% due to its poor aqueous solubility and extensive first pass metabolism. Formulation, characterization and evaluation of paclitaxel. Formulation and evaluation surender verma, amit kumar, vipul k. Formulation and evaluation of solid lipid nanoparticles of ramipril. Solid lipid nanoparticles are typically spherical with an average diameter between 1 and nm. Solid lipid nanoparticles have been extensively investigated for topical treatment of acne. Recently, increasing attention has been focused on these sln as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Solid lipid nanoparticles were prepared by hot homogenisation technique using glycerol distearate, tween 80 and millipore water. Quetiapine fumarate is an antipsychotic drug with poor oral bioavailability 9% due to firstpass metabolism.
Totally nine batches of sln was formulated by hot homogenization. Formulation and evaluation of solid lipid nanoparticle sln based topical gel of etoricoxib roohi kesharwani1, anupam sachan1, swati singh1, dilip patel2 1dayanand dinanath college, institute of pharmacy, kanpur, india. Formulation and evaluation of metoclopramide solid lipid nanoparticles for rectal suppository. Incorporation of solid lipid nanoparticles into gel. Solid lipid nanoparticles of simvastatin for improved oral delivery solid lipid nanoparticles have been increasingly utilised for improving. Formulation and characterization of rivastigmine loaded.
Simvastatin solid lipid nanoparticles for oral delivery. Solid lipid nanoparticles sln mainly comprise lipids that are in solid phase at the room temperature and surfactants for emulsification, the mean diameters of which range from 50 to nm for colloid drug delivery applications. Zidovudine sanjay singh, ajay kumar dobhal, achint jain, jayant kumar pandit, and subhashis chakraborty department of pharmaceutics, institute of technology, banaras hindu. Formulation and evaluation of solid lipid nanoparticulate gel.
Formulation and evaluation of nimodipineloaded solid. They typically contain a hydrophobic solid matrix core with a. Slns are small sized lipid nanoparticles composed of biocompatible and biodegradable solid lipids. Formulation and microbiological evaluation rosario pignatello 1,2, id, antonio leonardi 1, virginia fuochi 3, giulio petronio petronio 3, antonio s.
Preparation and characterization of glyceryl monostearate solidlipid nanoparticles by high shear homogenization. However, few studies developing morin formulations have been reported. Formulation and evaluation of solid lipid nanoparticulate gel for antiacne therapy ajay kumar, neha gulati, randhir gupta, koshy mk and shubhini a. Nanoparticles made from solid lipids are attracting. To overcome the side effects and to increase the bioavailability of ramipril, solid lipid nanoparticles of ramipril are prepared by using lipids glyceryl monostearate. A modern formulation approach in drug delivery system s. The aim of this study was to prepare, characterize and evaluate solid lipid nanoparticles and nanostructured lipid carriers containing phycocyanin from spirulina platensis. Greco 1 and pio maria furneri 3 id 1 section of pharmaceutical technology, department of drug sciences, university of catania. Formulation and evaluation of nimodipineloaded solid lipid nanoparticles delivered via lymphatic transport system.
Formulation development and evaluation of paclitaxel. Zaltoprofen loaded solid lipid nanoparticles for topical. Carbopol 940 was incorporated in nanosuspension and soaked overnight. The formulation of ssdloaded solid lipid nanoparticles is depicted in table 1. Solid lipid nanoparticles typically are spherical with. School of pharmaceutical sciences, lovely professional university 2, phagwara 144411, punjab, india. Lycopene belongs to the carotenoids that shows good pharmacological properties including antioxidant, antiinflammatory and anticancer. In order to improve the oral bioavailability of raloxifene, raloxifene loaded solid lipid nanoparticles sln have been developed using compritol 888 ato as lipid carrier and pluronic f68. Formulation and evaluation of solid lipid nanoparticle sln. The present work aims at preparing aqueous suspension of solid lipid nanoparticles containing chitosan. Pdf solid lipid nanoparticles are typically spherical with an average diameter between 1 and nm. Comparison of cytotoxicity between polyester nanoparticles and solid lipid nanoparticles.
Particle size analysis of silver sulfadiazine solid lipid nanoparticle is characterized by using the instrument microtrac nanotrac a150. They combine the advantages of liposomes, polymeric nanoparticles, and emulsions while minimizing some of their individual disadvantages 53,54. Present work is an attempt to improve oral bioavailability of quetiapine fumarate by incorporating in solid lipid nanoparticles sln. Hydrochloride in cationic solid lipid nanoparticles. At room temperature the particles are in solid state. Request pdf formulation and evaluation of solid lipid nanoparticles of a water soluble drug. Retinolloaded solid lipid nanoparticles of compritol released the drug more rapidly and to a higher extent when compared with conventional vehicles jenning et al. Amongst various nanoparticles, solid lipid nanoparticles slns, introduced in 1991 represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles. All the prepared silver sulfadiazine solid lipid nanoparticle. Introduction solid lipid nanoparticle sln 1 dispersions have been proposed as a innovative type of colloidal drug. Solid lipid nanoparticles slns are important because of their size and stability. The aim of present work was to formulate and evaluate dasatinib dst loaded solid lipid nanoparticles slns as a potential anticancer drug delivery system by enhancing its solubility.
Zidovudine the present investigation was undertaken to develop solid lipid nanoparticles sln of a. Formulation and evaluation of solid lipid nanoparticle sln based. Six quetiapine fumarate sln formulations were developed using three different lipids by hot homogenisation followed by ultrasonication. The results showed that the type and amount of lipid and surfactant had a significant effect on the particle size distribution. Thermal analysis of prepared solid lipid nanoparticles gave indication of solubilisation of drugs within lipid matrix. Formulation and evaluation of gemcitabineloaded solid lipid. Preparation, characterization and evaluation of quetiapine. Transmission electron microscopy showed that sln had round and spherical shape in form of solid dispersion or drug. Technological developments and in vivo techniques to evaluate their interaction with the skin mariella bleve, franca pavanetto and paola perugini department of drug sciences. Formulation and evaluation of morinloaded solid lipid. It is an alternative carrier system to tradition colloidal carriers. Formulation and evaluation of solid lipid nanoparticles of quetiapine fumarate and quetiapine hemifumarate for brain delivery in rat model. Solid lipid nanoparticles are a new generation of colloidal drug carrier systems and consist of surfactantstabilized lipids that are solid both at room and body temperatures 52. Formulation of poloxamer 407 with compritol and drug f9 produced highest in.
Thakur department of pharmaceutics, krupanidhi college of pharmacy, bangalore560 034, india. School of pharmaceutical sciences, lovely professional university 2, phagwara. Formulation and evaluation of solid lipid nanoparticles of a water soluble drug. This rapid release was attributed to the burst effect from the. The purpose of this study was to formulate and characterize metoclopramide solid lipid nanoparticles mcp. These nanoparticles were then incorporated into a gel using carbopol and trietnanolamine optimised formulation was chosen according to its particle size, as it was for topical use. Formulation, development and invitro evaluation of lopinavir loaded solid lipid nanoparticles kaushal p. Zidovudine sanjay singh, ajay kumar dobhal, achint jain, jayant kumar pandit, and subhashis chakraborty department of pharmaceutics, institute of technology, banaras hindu university. The objective of this research is to formulate and evaluate solid lipid nanoparticles containing acyclovir by various phospholipids and surfactants using hot homogenization technique. Formulation and evaluation of solid lipid nanoparticles. Formulation and evaluation of solid lipid nanoparticulate. Ajay kumar, neha gulati, randhir gupta, koshy mk and shubhini a.
Formulation and evaluation of solid lipid nanoparticles loaded with bacoside rich extract rajesh kumar 1, 2 and rajeev garg 3 ikg punjab technical university 1, kapurthala 144603, punjab, india. Solid lipid nanoparticle an overview sciencedirect topics. Fourier transformation infrared spectroscopy ftir showed the absence of new bands for loaded solid lipid nanoparticles indicating no interaction between drugs and lipid matrix and being only dissolved in it. Oct 11, 2017 the aim of this study was to prepare, characterize and evaluate solid lipid nanoparticles and nanostructured lipid carriers containing phycocyanin from spirulina platensis. Formulation development and evaluation of paclitaxel loaded solid lipid nanoparticles using glyceryl monostearate a. Slns are in submicron range 50nm and are composed of physiologically tolerated lipid components. Ramipril is an antihypertensive agent used in the treatment of hypertension. The present work aims at preparing aqueous suspension of solid lipid nanoparticles containing chitosan ct which is a biopolymer that exhibits a number of interesting properties which include controlled drug delivery. Recently, solid lipid nanoparticles have received much attention by the researchers owing to its biodegradability, biocompatibility and the ability to deliver a wide range of drugs. Formulation and evaluation of solid lipid nanoparticles of a. Formulation and evaluation of solid lipid nanoparticle sln japs.
The solid lipid nanoparticles slns possess a lipid core matrix in the nanometer range stabilized by a layer of surfactants. Slns are made from solid lipids, which combines the advantages of other innovative carrier systems while at the same time minimizes the. The formulation was stirred with alkalinizing agent triethanolamine till ph 6 and the gel of desired viscosity is obtained. It is an alternative carrier system to tradition colloidal carriers, such as, emulsions, liposomes, and polymeric micro and nanoparticles. Formulation and evaluation of chitosan solid lipid nanoparticles of. Pdf formulation and evaluation of solid lipid nanoparticles of. They have been used as ideally suited drug delivery systems for the proteins vaccines and other drugs for controlled release compared to other colloidal drug delivery systems.
Formulation and physicochemical characterization of. Research open access formulation and evaluation of. Formulation and evaluation of solid lipid nanoparticles of water. Particle size analysis of sln showed a size range of 24. Saraf solid lipid nanoparticles sln are colloidal carrier systems providing controlled release profiles for many substances. Formulation and characterization of rivastigmine loaded solid.
Formulation development and evaluation of atorvastatin calcium loaded solid lipid nanoparticles upadhyay n a, mohan g a, sharma s a, shukla t p a, mathur a a, manmohan k anims institute of pharmacy, nims university, shobha nagar, jaipur303121, india corresponding author. The solid lipid nanoparticles sln of chitosancbz were. Slns are small sized lipid nanoparticles composed of biocompatible and. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. Research open access formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine rahul nair, ashok ck kumar, vishnu k priya, chakrapani m yadav and prasanna y raju abstract the present work aims at preparing aqueous suspension of solid lipid nanoparticles containing chitosan ct which. Formulation and evaluation of solid lipid nanoparticles of. However, as a result of very low aqueous solubility, it has a limited systemic absorption, following oral administration. Slns were prepared via hot microemulsion method with slight. In order to improve the oral bioavailability of raloxifene, raloxifene loaded solid lipid nanoparticles sln have been developed using compritol 888 ato as lipid carrier and pluronic f68 as. Recently, solid lipid nanoparticles have received much attention by the researchers owing to its biodegradability, biocompatibility and the ability to. Development and evaluation of solid lipid nanoparticles of.
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